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What evidence or research supports your claims about Active Iron?

Studies carried out in conjunction with Trinity College Dublin have shown that the iron in Active Iron is better absorbed and better tolerated than standard ferrous sulphate iron products on the market.

Iron is absorbed via the divalent metal transporter-1 (DMT-1) which is most active in the upper intestines (duodenum). Active Iron targets the release of iron in the upper duodenum.

In a clinical study, the amount of iron absorbed from Active Iron was double that absorbed from the same dose of conventional ferrous sulphate (112±58% increase in serum iron with Active Iron vs 50±26% with standard ferrous sulphate) (Wang et al. 2017, Acta Haematologica, 138: 223-232). Additionally, this study showed that iron absorption was greatest among those with low iron stores. This is because the DMT-I is more active in those with lower iron stores.

Iron can cause the formation of reactive oxygen species (ROS) which can cause oxidative stress, damaging cells in the stomach. Active Iron causes significantly less ROS generation and less damage to the gastrointestinal tract. (Wang et al. 2017, Acta Haematologica, 138: 223-232).


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